De tering overwonnen

Honderd jaar geleden stond men machteloos tegen volksziekte nr. één: Tuberculose. Een longziekte met vaak fatale afloop. Pas met de komst van antibiotica, na de tweede wereldoorlog, kon men eindelijk echt de strijd aan met deze ziekte. De ziekte leek haast uitgeroeid, maar tegenwoordig steekt zij toch steeds vaker weer de kop op.

Geschiedenis van TBC

Tuberculose komt in veel vormen voor, maar longtuberculose is de meest voorkomende soort. Besmetting wordt veroorzaakt door het inademen van vochtige deeltjes met daarin tuberkelbacil. Deze bacil werd in 1882 ontdekt door Robert Koch. Tuberculose is al eeuwen een dodelijke ziekte, want tekenen van Tuberculose is zichtbaar op eeuwenoude opgegraven skeletten. Zelfs de Griekse geleerde, Hippocrates, maakte al melding van een ziekte die hij phthisis (= wegteren) noemde. Oorspronkelijk was Tuberculose een veeziekte met name bij koeien, de zogenaamde ‘parelziekte’. Door het drinken van ongepasteuriseerde melk raakten de mensen besmet en gecombineerd met en lage weerstand veroorzaakt door de slechte leefomstandigheden van de grote boerengezinnen, ontstond al snel een dodelijke epidemie. In deze tijd was er nog nauwelijks sprake van een echte medische wetenschap en had doktoren slechts klisma’s en aderlatingen als ‘geneesmiddelen’. Op zeer besmettelijke ziektes zoals Cholera en Tuberculose had men simpelweg gewoon geen antwoord. Allerlei vreemde theorieën staken in loop van tijd de kop op. Zo ontstond rond 1900 het beeld van de wegterende kunstenaar. Veel bekende kunstenaars en dichters, zoals Molière, Kafka, Goethe en Chopin, leden aan deze ziekte en zo was het beeld van de tering als ‘romantische modeziekte’ geboren. Alexandre Dumas schreef in zijn memoires, dat iedereen die ‘meetelde’ in de literatuur teringachtig was: “het behoorde tot de goede vorm om na elke hevige emotie wat bloed op te geven en voor het dertigste levensjaar te sterven”.

Genezing aan de horizon

In 1882 ontdekt Robert Koch de tuberkelbacil en de eerste stap op weg naar een genezing is daarmee gezet. Een eerste poging tot het vinden van een medicijn is het vaccin ‘oud-tuberculine’, een extract van dode tuberkelbacillen. Helaas werkte dit ‘medicijn’ eerder averechts, dan dat het genas. Toch bleek dit middel niet geheel nutteloos. In de vorm van de ‘Mantouxtest’ kon met tuberculine aangetoond worden of iemand in contact was geweest met Tuberculose. Met de ontdekking van de tuberkelbacil kwam eindelijk ook het besef dat de ziekte besmettelijk was en verdwenen de vreemde theorieën over hoe men aan de ziekte kwam. Een echt medicijn liet echter nog lang op zich wachten. De genezing werd nu gezocht in ‘gezonde lucht’ en dat was het startsein voor de bouw van vele sanatoria verspreid over Nederland. De meeste sanatoria werden gebouwd met geld, bijeengebracht door christelijke verenigingen of door vakbonden. In 1898 opende in Heiloo het eerste sanatorium haar deuren. De sanatoria waren niet alleen voor de rijken; ook de minderbedeelden konden naar sanatoria voor behandeling.

Het Gooi

In het begin was nog maar weinig bekend over de ziekte Tuberculose en ook de diagnostiek liet regelmatig te wensen over. De behandeling bestond daarom ook uit niet veel meer dan de patiënten goed te laten eten, veel te laten rusten en de hygiëne in acht nemen. En… frisse lucht! De patiënten in de sanatoria lagen een groot deel van de dag in op lighallen ongeacht het seizoen om maar zo veel mogelijk frisse lucht tot zich te nemen. Maar waar vind je deze frisse lucht. Tegenwoordig zijn we ons bewust van luchtvervuiling, maar toen verkeerde Nederland nog in de vaart van de Industriële Revolutie en waren de steden plekken met fabrieksschoorstenen en dicht op elkaar gebouwde woningen. Frisse lucht? Daarvoor moest je de stad dus ver achter je laten. Voor Amsterdamse ‘teringlijders’ was het Gooi de meest ideale plek voor de ‘frisse-lucht-behandeling’. Ver genoeg van de ‘rook uitbrakende’ schoorstenen, maar toch nog dichtbij genoeg voor de familie om op bezoek te komen. TBC-patiënten moesten vaak lang in de sanatoria verblijven en familie mocht helaas maar af en toe op bezoek komen in verband met besmettingsgevaar.

Een dorp op zich

Een sanatorium was bijna een dorp in een dorp. Het bestond uit meerdere paviljoens, mannen, vrouwen en kinderen uiteraard van elkaar gescheiden. Het had een eigen keuken, een eigen kerk, huisvesting voor het (verplegend) personeel, een bibliotheek en soms zelfs een eigen begraafplaats. Wanneer een sanatorium veel kinderen huisvestte, werd vaak ook een schooltje gebouwd.

Onderzoek en behandeling

Zoals al eerder gezegd, stond de medische wetenschap echt nog in de kinderschoenen voor wat Tuberculose betreft. Het opsporen van Tuberculose gebeurde aanvankelijk door de zogeheten Percussiemethode. De arts tikte dan op de borst om te horen of er tuberkels (ontstekingsknobbels) in de longen zaten. Met deze methode werd Tuberculose pas ontdekt wanneer de ziekte al vergevorderd was. Dankzij de komst van de microscoop kon ook ‘sputum’ (opgehoest slijm) onderzocht worden op de tuberkelbacil. Een grote doorbraak kwam door de komst van de röntgentechniek. De ziekte kon nu in een vroeg stadium al opgespoord worden, maar betekende wel dat men eerst ‘lipidiol’ (een contrastvloeistof) in de longen ingebracht kreeg met een rubberen slang. Geen pretje! Een andere opsporingsmethode was de bronchoscopie. Ook niet bepaald een prettig onderzoek, want nu werd een metalen buis ingebracht in de luchtpijp en met behulp van spiegeltjes en lampjes kon men dan tot in de bronchiën kijken. Een vreselijk onderzoek, maar het belang ervan is nog uit te leggen aan een volwassene. Maar aan een kind van vier jaar oud! De eerste behandelmethodes waren in het begin erg primitief door het ontbreken van een echt medicijn. Rust, reinheid en regelmaat bleven lang het devies. Toch gingen de doktoren soms over tot zeer drastische ingrepen om genezing te bereiken. Zo werd bij sommige patiënten een klaplong geforceerd of zelfs een long of een deel er van verwijderd. Om dit laatste te doen, moesten enkele ribben verwijderd worden, wat vaak blijvend een scheve houding bij de patiënten veroorzaakte.

Een echt medicijn

Ondertussen werd hard gezocht naar een echt medicijn tegen tuberculose en dat kwam met de ontwikkeling van streptomycine in 1944. In 1946 werd PAS (Para-Amino Salicylzuur) ontdekt en in 1952 Isonicotinezuur. Deze zogenaamde tuberculostatica waren in het beging helaas erg duur en nauwelijks voorradig, maar na een tijdje konden ze wel steeds meer worden toegepast. Dit betekende echter nog geen einde aan de sanatoria, want men bleef vasthouden aan langdurige rustkuren gecombineerd met ‘schone’ lucht. Zelfs nadat ‘ambulante’ behandeling, een concept overgewaaid uit de Verenigde Staten, ook effectief bleek te zijn, durfden de Nederlandse artsen de bedrust als ‘recept’ nauwelijks op te geven. Maar wanneer het tbc-sterftecijfer eind jaren ’50 flink begint te dalen met 60% dankzij antibiotica, krijgen de sanatoria te maken met ‘lege bedden’. Het einde van het sanatorium als behandelmethode is nabij!

TBC maakt een ‘come-back’

In de jaren ‘80 waren artsen en deskundigen in Europa ervan overtuigd dat in 2008 tuberculose als ziekte uitgeroeid zou zijn, maar het tegendeel is waar. Tuberculose is aan een ‘come-back’ bezig. De wereld is kleiner geworden, men reist de hele wereld over en zo komt men in contact met ziekten, die we in Europa hadden ‘uitgeroeid’. Voorlopig is de ziekte goed te genezen met antibiotica, maar inmiddels rukt een multi-resistente variant op in Nederland. In 2010 waren er 19 tuberculose-gevallen bij wie de antibiotica-kuur niet aansloeg. Artsen staan machteloos tegen deze TBC-stam, die op geen enkele bestaand medicijn reageert.

Misschien keert de tijd van ‘kuren’ in een sanatorium wel weer terug…

 

(Bron: Andere Tijden, NPO)

 

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